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Go beyond your typical stay in Upstate South Carolina

Apart hotel

Family friendly

Our top choices for Upstate South Carolina hotels

Premium bedding, in-room safe, individually furnished, laptop workspace

Carolina Camp Cedar

Pickens

Katlynn

AED 953 total

includes taxes & fees

17 May - 18 May

Quality Inn Seneca Clemson Area US-123

Downtown

William

AED 373 total

includes taxes & fees

9 Jun - 10 Jun

Signature Cottage, 2 Bedrooms | Living room | 43-inch Smart TV with cable channels, TV, Netflix

Clemson Memorabilia House

Clemson

Ashley

AED 873 total

includes taxes & fees

17 May - 18 May

Single Room, 1 King Bed, Non Smoking | Desk, laptop workspace, free WiFi

Deluxe Inn

Mauldin

AED 272 total

includes taxes & fees

17 May - 18 May

Carolina Inn Anderson Clemson Area

Anderson

AED 224 total

includes taxes & fees

17 May - 18 May

Hampton Inn Gaffney

Gaffney

Theresa

AED 347 total

includes taxes & fees

17 May - 18 May

Lakeside Lodge Clemson

Seneca

Valarie Tina

AED 497 total

includes taxes & fees

21 May - 22 May

Best Western Plus Clemson Hotel & Conference Center

Clemson

Alexandra

AED 447 total

includes taxes & fees

21 May - 22 May

Fairfield Inn & Suites Seneca Clemson Univ Area

Seneca

Crystal

AED 522 total

includes taxes & fees

18 May - 19 May

Aloft Greenville Downtown

Greenville Downtown

Danilo

AED 539 total

includes taxes & fees

31 May - 1 Jun

Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG

Anderson

Lauren

AED 432 total

includes taxes & fees

12 Jun - 13 Jun

Clemson University's James F. Martin Inn

Clemson

Sara

AED 607 total

includes taxes & fees

21 May - 22 May

Comfort Inn & Suites Greer - Greenville

Greer

Paula

AED 419 total

includes taxes & fees

25 May - 26 May

Embassy Suites Greenville Golf Resort & Conference Center

Greenville

Kylasha

AED 480 total

includes taxes & fees

17 May - 18 May

In-room safe, desk, blackout drapes, iron/ironing board

The Abernathy of Clemson

Clemson

William

AED 560 total

includes taxes & fees

17 May - 18 May

Hampton Inn Easley

Easley

Jenine

AED 498 total

includes taxes & fees

7 Jun - 8 Jun

Standard Room, 1 King Bed, Non Smoking, Jetted Tub | Desk, laptop workspace, blackout drapes, iron/ironing board

Best Western Seneca-Clemson

Seneca

Judith

AED 395 total

includes taxes & fees

25 May - 26 May

The Inn at Patrick Square

Clemson

Roberto

AED 648 total

includes taxes & fees

17 May - 18 May

Hampton Inn Greer Greenville, SC

Greer

Alberto

AED 557 total

includes taxes & fees

4 Jun - 5 Jun

Quality Inn Clinton - Laurens I-26

Clinton

Christine

AED 271 total

includes taxes & fees

7 Jun - 8 Jun

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Vacation Rentals in Upstate South Carolina

Cabin

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Seneca

"Awesome place "

Cottage

< 3 Mi to Dtwn: Modern Cottage in Greenville!

Greenville

Mobile Home

Cabin, 2 Bedrooms, Non Smoking (No Pets, Linens Included) | In-room dining

Carolina Landing RV Resort - Caravan Park

Fair Play

"Arrived after office closing, getting pack with key was no problem. The gate code was not on packet, had to call emergency number to get it and got quite the attitude with whom answered."

Aparthotel

Full-size fridge, microwave, oven, stovetop

stayAPT Suites Greenville-Haywood Mall

Greenville

"Great place, clean and quiet."

Apartment

Deluxe Two Bedroom (Self Check-in with Virtual Front Desk) | Living area | 55-inch flat-screen TV with digital channels, TV, streaming services

Mint House Greenville Downtown by Kasa

Greenville Downtown

"Great spot"

Cottage

Claires Cottage ~ 4 Mi to Downtown Greenville!

Greenville

"Great trip. The small cottage was perfect for my wife and I and the owner was very responsive."

Cottage

8 Mi to Clemson: Peaceful Family Home w/ Yard

Seneca

"The place was all out perfect the owner was polite and perfect. It was a very peaceful place to stay thank you so much."

Apartment

Serene Travelers Rest Apartment: 7 Mi to Downtown!

Travelers Rest

"The best time ever. My wife and I enjoyed our Honeymoon and stay here. We will come back every year for our Anniversary now and also to vacation here. The area was beautiful, quiet, and safe. We had everything we needed. No other vacation spot in South Carolina can compete. Thank you for our wonderful stay and perfect memories! "

Cottage

Cozy Greenville Bungalow ~ 2 Mi to Downtown!

Greenville

"Amazing place. Great host. "

Cottage

9 Mi to Devils Fork State Park: Getaway w/ Porch!

Tamassee

"Fall weekend getaway and this was perfect location. Loved the back porch for coffee and views of the sun through all the colorful leaves. Felt like we were away from it all but just a short drive to restaurants, stores, lakes and parks!!!"

Cottage

Cozy Home in Historic Area ~ 2 Mi to Main St!

Greenville

"Absolutely adorable property. Little bit of an interesting part of town. We weren’t spending a bunch of time on property so it didn’t mater. Super close to down town and the house is well kept. "

Cottage

Cleveland Home w/ South Saluda Fishing Access

Cleveland

"This was a fishing trip that myself and a couple of my friends went on. The cabin was exactly as described in the listing and then some. Very clean and had every amenity you could think of. The host lives next door and went above and beyond making sure we had everything we needed and were comfortable. He even lent us his state pass to get into the parks and supplied his vast knowledge of where and what to use for fishing in the creeks. Will definitely be going back sometime in the near future."

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Stay near popular Upstate South Carolina attractions

Clemson University

4.8/5 (1,439 reviews)

Enjoy the collegiate vibe when you visit Clemson University, during your travels in Clemson. Experience the area's theater scene or attend a football game.

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Learn more about Upstate South Carolina

Experience the family-friendly area of Upstate South Carolina—live music, restaurants, and sights from Discovery Island Water Park to Frankie's Fun Park.

See all hotels in Upstate South Carolina

Top Upstate South Carolina Hotel Reviews

Best Western Plus Clemson Hotel & Conference Center

8/10 Good

"Room was clean bed slept very good. Everyone that worked. There were very accommodating great location. This is my fourth time staying at this hotel."

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

2/10 Terrible

"Felt embarrassed by Breakfast staff First of all they have not issued my breakfast tickets when i checked in( for which i paid). And then when i went to have my breakfast and they asked for a ticket which i didnt have, then i said let me go and get the ticket Then the breakfast lady came running behind me and when i was talking to the receptionist, she was tell her that some thing like “not everyone will get breakfast” and ran inside to get manager By the time, the manager came and asked is there any problem, she gave me breakfast ticket after looking at my resrvation. I felt sooo embarrassed by that breakfast staff. Which i never felt like at any hotels Not even at motels."

Hyatt Place Greenville Downtown

8/10 Good

"I had a pleasant stay. The staff was friendly and helpful. Room was nice and clean and I had a city view, which was great. The only downside (and it's not that extreme) was their breakfast. It wasn't bad but just not may choices. I just prefer hot breakfast if I'm going to eat. I would definitely stay again."