Comfort Inn & Suites Sikeston I-55
Travelers find productivity and relaxation at this convenient hotel, where the indoor pool offers a refreshing break after meetings or sightseeing
Photo gallery for Comfort Inn & Suites Sikeston I-55





Just off I-55, Comfort Inn & Suites Sikeston I-55 provides a practical base for travelers. Guests can swim in the indoor pool, use the laundry facilities, connect with in-room WiFi, maintain fitness routines at the gym, or handle work matters in the business center.
Reviews
8.4 out of 10
Very good
Popular amenities
The current price is AED 318
AED 363 total
includes taxes & fees
22 Feb - 23 Feb
Room options
Check availability for these dates
Available filters for rooms
Showing 5 of 5 rooms
View all photos for Standard Room, 2 Queen Beds, Non Smoking

Standard Room, 2 Queen Beds, Non Smoking
8.0 out of 10
Very good
(11 reviews)
Highlights
Air conditioning
Refrigerator
Private bathroom
Coffee/tea maker
Cable/satellite channels
Desk
View all photos for Suite, 1 King Bed with Sofa bed, Non Smoking

Suite, 1 King Bed with Sofa bed, Non Smoking
Highlights
Air conditioning
Refrigerator
Sofa bed
Separate bedroom
Private bathroom
Coffee/tea maker
Cable/satellite channels
Desk
View all photos for Room, 1 King Bed, Accessible, Non Smoking

Room, 1 King Bed, Accessible, Non Smoking
9.0 out of 10
Wonderful
(2 reviews)
Highlights
Air conditioning
Private bathroom
Coffee/tea maker
Cable/satellite channels
Desk
View all photos for Room, 2 Queen Beds, Accessible, Non Smoking

Room, 2 Queen Beds, Accessible, Non Smoking
10.0 out of 10
Exceptional
(4 reviews)
Highlights
Air conditioning
Private bathroom
Coffee/tea maker
Cable/satellite channels
Desk
View all photos for Standard Room, 1 King Bed, Non Smoking

Standard Room, 1 King Bed, Non Smoking
8.0 out of 10
Very good
(14 reviews)
Highlights
Air conditioning
Refrigerator
Private bathroom
Coffee/tea maker
Cable/satellite channels
Desk
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includes taxes & fees
13 Feb - 14 Feb
About the neighborhood

109 Matthews Ln, Sikeston, MO, 63801
What's nearby
Southeast Missouri State University33 min drive - 62.0 km- City of Miner Convention Center5 min walk - 0.4 km
- Sikeston Depot Museum5 min drive - 4.8 km
- Saint Francis Medical Center28 min drive - 57.8 km
- Isle Casino Cape Girardeau33 min drive - 61.2 km
Getting around
- Cape Girardeau, MO (CGI-Cape Girardeau Municipal)29 min drive
Restaurants
- Lambert's Cafe17 min walk
- Buffalo Wild Wings5 min drive
- Burger King4 min drive
- Starbucks6 min drive
- Imo's Pizza6 min drive
About this property
Comfort Inn & Suites Sikeston I-55
Similar properties

Best Western Plus Sikeston I-55
Best Western Plus Sikeston I-55
- Pool
- Breakfast included
- Pet friendly
- Parking included
8.4 out of 10, Very Good, 1,003 reviews
The price is AED 312
AED 356 total
includes taxes & fees
22 Feb - 23 Feb
Property amenities
Room amenities
Policies
Important information
Optional extras
- Pet fee: USD 20 per pet, per night
- Service animals are exempt from fees
The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.
You need to know
Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
This property affirms that it follows the cleaning and disinfection practices of Commitment to Clean (Choice)
Property is also known as
Comfort Inn Sikeston Hotel
Comfort Inn Sikeston
Frequently asked questions
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Reviews
Comfort Inn & Suites Sikeston I-55 Reviews
8.4
Very Good
8.6
Cleanliness
8.6
Location
8.8
Staff & service
8.2
Property conditions & facilities
Reviews
28 December 2025
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Stayed 1 night in Dec 2025
10/10 Excellent
Connie
7 November 2025
Liked: Cleanliness, property conditions & facilities
Connie
Stayed 1 night in Nov 2025
10/10 Excellent
Lisa
18 July 2025
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Lisa
Stayed 1 night in Jul 2025
8/10 Good
Amanda
15 March 2025
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Amanda
10/10 Excellent
Kimberly
22 March 2025
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Kimberly
Stayed 1 night in Mar 2025
10/10 Excellent
Peggy
14 May 2025
Liked: Cleanliness, staff & service, property conditions & facilities
Peggy
Stayed 2 nights in May 2025
8/10 Good
John
9 May 2025
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Good stay
John
Stayed 1 night in May 2025
8/10 Good
Denise
10 March 2025
Denise
Stayed 1 night in Feb 2025
10/10 Excellent
Tammi
22 August 2023
Liked: Cleanliness, staff & service, property conditions & facilities
Tammi
Stayed 1 night in Aug 2023
10/10 Excellent
John
14 April 2024
Liked: Cleanliness, staff & service, property conditions & facilities
John
Stayed 1 night in Apr 2024
10/10 Excellent
Michael
27 December 2024
Liked: Cleanliness, staff & service, property conditions & facilities
Michael
Stayed 1 night in Dec 2024
8/10 Good
Dylan
26 May 2024
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Dylan
Stayed 1 night in May 2024
10/10 Excellent
Roger
20 January 2025
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Roger
Stayed 1 night in Jan 2025
10/10 Excellent
Drew
19 September 2024
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Perfect Pit Stop
Drew
Stayed 1 night in Sep 2024
10/10 Excellent
Timothy
11 May 2025
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Timothy
Stayed 1 night in May 2025
10/10 Excellent
Mark
30 September 2024
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Mark
Stayed 1 night in Sep 2024
10/10 Excellent
Diane
15 February 2025
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Diane
Stayed 1 night in Feb 2025
8/10 Good
JOHN
29 May 2024
Liked: Property conditions & facilities
JOHN
Stayed 1 night in May 2024
10/10 Excellent
Susan
13 March 2024
Liked: Cleanliness, staff & service, property conditions & facilities
Susan
Stayed 1 night in Mar 2024
8/10 Good
Verified traveler
29 November 2024
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Just one night
Verified traveler
Stayed 1 night in Nov 2024
8/10 Good
Latrisha
13 May 2024
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Latrisha
Stayed 2 nights in May 2024
10/10 Excellent
Gail
17 May 2024
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Gail
Stayed 1 night in May 2024
10/10 Excellent
Marsha
22 March 2025
Liked: Property conditions & facilities
Marsha
Stayed 1 night in Mar 2025
10/10 Excellent
Tina
9 September 2023
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Tina
Stayed 1 night in Sep 2023
8/10 Good
Amelia
29 July 2024
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Amelia
Stayed 1 night in Jul 2024

















